Pain control by melatonin: Physiological and pharmacological effects

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Pain control by melatonin: Physiological and pharmacological effects

Pain and anxiety are the most common neurological responses to many harmful or noxious stimuli and their management clinically is often challenging. Many of the frequently used morphine-based drugs, non-steroid anti-inflammatory drugs and acetaminophen, while efficient for treating pain, lead to patients suffering from several unwanted side effects. Melatonin, produced from the pineal body is a...

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Background Acute pain and distress during medical procedures are commonplace in newborn admitted to Intensive Care Unit and can have detrimental effects, if uncontrolled. Accumulating evidence suggests that neonate, as older children, could benefice of non pharmacological interventions (NPIs) to relive mild to moderate pain, anxiety and discomfort from minor invasive procedures. [1] These thera...

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Pain control in newborn: pharmacological interventions

Material and methods To assess efficacy and safety of PIs for procedural pain in neonate, a literature search covering the period 20002015 via Medline and Cochrane Library database, was undertaken. PIs were evaluated in relation to intubation (INT), mechanical ventilation (MV)and postoperative analgesia (POp) in preterm and fullterm infants. Efficacy of PIs in controlling procedural pain and di...

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Effects of Melatonin and Vitamin E on Peripheral Neuropathic Pain in Streptozotocin-Induced Diabetic Rats

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ژورنال

عنوان ژورنال: Experimental and Therapeutic Medicine

سال: 2016

ISSN: 1792-0981,1792-1015

DOI: 10.3892/etm.2016.3565